A total of 55 subjects were included in this cross-sectional study: 20 with PPA and 35 with bvFTD. We also described mood and behavioral profiles of participants with mild to moderate probable bvFTD and PPA. We aim to examine the discriminative capacity of the most frequently used cognitive tests in their Spanish version for the context of dementia evaluation as well as the qualitative aspects of the neuropsychological performance such as the frequency and type of errors, perseverations, and false positives that can best discriminate between bvFTD and PPA. Therefore, it is important to identify cognitive tests that can distinguish the distinct FTD variants to reduce misdiagnosis and best tailor interventions. Presentations of dementia type or variants dominated by personality change or aphasia are frequently misinterpreted as psychiatric illness, stroke, or other conditions. The differential diagnosis among the behavioral variant of frontotemporal dementia FTD (bvFTD) and the linguist one primary progressive aphasia (PPA) is challenging. 3Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States.2Psychology Department, University Institution of Envigado, Envigado, Colombia.1Neuroscience Group of Antioquia, The University of Antioquia, Medellín, Colombia.Published by the BMJ Publishing Group Limited.Lina Velilla 1 Jonathan Hernández 2 Margarita Giraldo-Chica 1 Edmarie Guzmán-Vélez 3 Yakeel Quiroz 1,3 † Francisco Lopera 1 * † Montreal Cognitive Assessment-Beijing cognitive impairment mild stroke transient ischemic attack. ![]() The predominant cognitive deficits were characteristic of frontal-subcortical impairment, such as visuomotor speed (46.08%), attention/executive function (42.16%) and visuospatial ability (40.20%).Ī MoCA-Beijing cut-off score of 22/23 is optimally sensitive and specific for detecting CI after mild stroke, and TIA in the acute stroke phase, and is recommended for routine clinical practice. The optimal cut-off point for MoCA-Beijing in discriminating patients with CI from those with no cognitive impairment (NCI) was 22/23 (sensitivity 85%, specificity 88%, positive predictive value=91%, negative predictive value=80%, classification accuracy=86%). Most stroke and TIA patients were in their 50s (53.95☑1.43 years old), with greater than primary school level of education. CI was defined by 1.5 SD below the established norms on a formal neuropsychological test battery. They received the MoCA-Beijing and a formal neuropsychological test battery. We aimed to establish the cut-off point of the Montreal Cognitive Assessment (MoCA-Beijing) in screening for cognitive impairment (CI) within 2 weeks of mild stroke or transient ischaemic attack (TIA).Ī total of 80 acute mild ischaemic stroke patients and 22 TIA patients were recruited. 8 Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China China National Clinical Research Center for Neurological Diseases, Beijing, China Department of Neurology, Tiantan Clinical Trial and Research Center for Stroke, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. ![]()
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